LCC Papers

Patient-derived organoid models to decode liver metabolism and pathophysiology

Benjamin J. Dwyer and Janina E.E. Tirnitz-Parker

Trends in Endocrinology & Metabolism

March 2025

https://doi.org/10.1016/j.tem.2024.07.019

FBP1 controls liver cancer evolution from senescent MASH hepatocytes

Li Gu, Yahui Zhu, Shuvro P. Nandi, Maiya Lee, Kosuke Watari, Breanna Bareng, Masafumi Ohira, Yuxiao Liu, Sadatsugu Sakane, Rodrigo Carlessi, Consuelo Sauceda, Debanjan Dhar, Souradipta Ganguly, Mojgan Hosseini, Marcos G. Teneche, Peter D. Adams, David J. Gonzalez, Tatiana Kisseleva, The Liver Cancer Collaborative, Janina E. E. Tirnitz-Parker, M. Celeste Simon, Ludmil B. Alexandrov & Michael Karin

Nature

January 2025

https://doi.org/10.1038/s41586-024-08317-9

Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy 

Ziyi Li, Rhea Pai, Saurabh Gupta, Jennifer Currenti, Wei Guo, Anna Di Bartolomeo, Hao Feng, Zijie Zhang , Zhizhen Li, Longqi Liu, Abhishek Singh, Yinqi Bai8, Bicheng Yang, Archita Mishra, Katharine Yang, Liang Qiao, Michael Wallace, Yujia Yin, Qiang Xia, Jerry Kok Yen Chan, Jacob George, Pierce Kah-Hoe Chow, Florent Ginhoux & Ankur Sharma

Nature Cancer

January 2024

https://doi.org/10.1038/s43018-023-00672-2

Oncofetal reprogramming in tumour development and progression

Ankur Sharma, Camille Blériot, Jennifer Currenti and Florent Ginhoux

Nature Review Cancer

October 2022

https://doi.org/10.1038/s41568-022-00497-8

Charting spatial ligand-target activity using Renoir

Narein Rao, Rhea Pai, Archita Mishra, Florent Ginhoux, Jerry Chan, Ankur Sharma, Hamim Zafar

bioRxiv 

April 2023

https://doi.org/10.1101/2023.04.14.536833

Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Jennifer Currenti, Archita Mishra, Michael Wallace, Jacob George, Ankur Sharma

Biochemical Society Transactions

April 2023

https://doi.org/10.1042/BST20220157