LCC Papers

Inhibition of the Caveolin-1 pathway promotes apoptosis and overcomes pan-tyrosine kinase inhibitor resistance in hepatocellular carcinoma

Tasnuva D. Kabir, Samuel Beck, Lisa M. Stuart, Ji Li, Rui Hou, Peiwen Liu, Shelby Margolius, Claire Kim, Yu Suk Choi, Edward R. Bastow, Dianne J. Beveridge, Lisa Spalding, Ziyi Li, Florent Ginhoux, Pierce Chow, Michael Phillips & Andrew D. Redfern, on behalf of The Liver Cancer Collaborative, George C. Yeoh, Alistair Forrest, Andrew J. Woo, Ankur Sharma, Jacob George, Geoffrey McCaughan & Peter J. Leedman
Nature Cell Death and Disease
July 2025
https://doi.org/10.1038/s41419-025-07887-4

Patient-derived organoid models to decode liver metabolism and pathophysiology

Benjamin J. Dwyer and Janina E.E. Tirnitz-Parker
Trends in Endocrinology & Metabolism
March 2025
https://doi.org/10.1016/j.tem.2024.07.019

FBP1 controls liver cancer evolution from senescent MASH hepatocytes

Li Gu, Yahui Zhu, Shuvro P. Nandi, Maiya Lee, Kosuke Watari, Breanna Bareng, Masafumi Ohira, Yuxiao Liu, Sadatsugu Sakane, Rodrigo Carlessi, Consuelo Sauceda, Debanjan Dhar, Souradipta Ganguly, Mojgan Hosseini, Marcos G. Teneche, Peter D. Adams, David J. Gonzalez, Tatiana Kisseleva, The Liver Cancer Collaborative, Janina E. E. Tirnitz-Parker, M. Celeste Simon, Ludmil B. Alexandrov & Michael Karin
Nature
January 2025
https://doi.org/10.1038/s41586-024-08317-9

Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy 

Ziyi Li, Rhea Pai, Saurabh Gupta, Jennifer Currenti, Wei Guo, Anna Di Bartolomeo, Hao Feng, Zijie Zhang , Zhizhen Li, Longqi Liu, Abhishek Singh, Yinqi Bai8, Bicheng Yang, Archita Mishra, Katharine Yang, Liang Qiao, Michael Wallace, Yujia Yin, Qiang Xia, Jerry Kok Yen Chan, Jacob George, Pierce Kah-Hoe Chow, Florent Ginhoux & Ankur Sharma
Nature Cancer
January 2024
https://doi.org/10.1038/s43018-023-00672-2

Oncofetal reprogramming in tumour development and progression

Ankur Sharma, Camille Blériot, Jennifer Currenti and Florent Ginhoux
Nature Review Cancer
October 2022
https://doi.org/10.1038/s41568-022-00497-8


Charting spatial ligand-target activity using Renoir

Narein Rao, Rhea Pai, Archita Mishra, Florent Ginhoux, Jerry Chan, Ankur Sharma, Hamim Zafar
bioRxiv 
April 2023
https://doi.org/10.1101/2023.04.14.536833


Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

Jennifer Currenti, Archita Mishra, Michael Wallace, Jacob George, Ankur Sharma
Biochemical Society Transactions
April 2023
https://doi.org/10.1042/BST20220157